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Superficial BCC may resemble Bowen’s disease, seborrhoeic keratosis, lichen planus-like keratosis, intraepidermal eccrine porocarcinoma in situ, eczema and psoriasis (3, 4). It favours the trunk and extremities, in contrast to the other subtypes, which favour more sun-exposed areas, such as the head and neck. Moreover, superficial BCC has a tendency to occur in younger patients than the other subtypes, with a mean age of 57 years at the time of diagnosis (5).

A MEDLINE search of the literature in English was conducted for the cases using the words and phrases “basal cell carcinoma” paired with the term “psoriasis”. A total of 1,004 articles were found, from which we have chosen only those related to BCC masquerading as psoriasis. Finally, we analysed 4 case reports (Table SI). Hanna et al. (6) described a psoriasis-like scaly red-pink patch of BCC located on the left lower back of a 63-year-old man. Liebman et al. (7) found an erythematous patch with focal erosion originally diagnosed as psoriasis. The lesion was situated on the right elbow of a 49-year-old man. Biopsy revealed superficial BCC. Stefannelo et al. (8) reported the case of 63-year-old man with scaly plaques mimicking psoriasis. However, dermoscopy suggested BCC. Histopathological examination confirmed the diagnosis of superficial BCC. Powell & Mackey (9) described a psoriasis-like ovoid erythematous lesion with atrophy, central scaling and raised edge. It was situated on the anterior chest wall of a 62-year-old man. Biopsy revealed superficial BCC.

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Cases of superficial BCC imitating psoriasis reported in the literature only include patients with concomitant psoriasis. Thus the cases reported here are unique.

Dermoscopy is a valuable aid in assessing skin tumours, and is also useful in evaluating inflammatory skin diseases. It may be helpful in differentiation of psoriatic plaques from superficial BCC. The significant dermo-scopic features that distinguish BCC from other lesions are: scattered vascular pattern, milky-pink background, telangiectatic or atypical vessels, arborizing microvessels, and brown dots or globules. Homogenous global vascular pattern, light-red background and red dots are specific for psoriasis. The presence of these 3 features and lack of arborizing vessels, including arborizing micro vessels, are most helpful in differentiation of psoriasis from superficial BCC (10, 11).

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Early correct diagnosis is important, because psoriasis treatment methods can have a negative effect on misdiagnosed BCC. The role of long-term topical corticosteroid usage and risk of skin cancer is still unknown. However, it has been reported that treatment with local steroids may have contributed to malignant transformation (9, 12, 13). Moreover, phototherapy and photochemotherapy, which are frequently used in psoriasis, are known as risk factors for skin cancer (14, 15).

In conclusion, based on the 2 patients reported here, it must be emphasized that, in some cases, clinical examination alone is not sufficient to make an accurate diagnosis. Therefore, it is highly recommended to use dermoscopy to help differentiate inflammatory lesions from BCC in daily clinical practice. Of course, all clinically unclear lesions should be biopsied for histological examination.

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