Epiduo and Epiduo Forte can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Epiduo or Epiduo Forte. These lists don’t include all possible side effects.
For more information on the possible side effects of Epiduo and Epiduo Forte, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome.
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Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to report to the FDA a side effect you’ve had with Epiduo or Epiduo Forte, you can do so through MedWatch.
Mild side effects
Mild side effects of Epiduo and Epiduo Forte can include:*
- dry skin
- rash†
- eczema (a condition that causes cracked, itchy, and red, darker brown, purple, or gray patches of skin)
- skin discoloration
Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.
* This is a partial list of mild side effects from Epiduo and Epiduo Forte. To learn about other mild side effects, talk with your doctor or pharmacist, or visit the prescribing information for both Epiduo and Epiduo Forte. † This mild side effect is discussed in more detail below in “Side effect details.”
Serious side effects
Serious side effects from Epiduo and Epiduo Forte aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
Serious side effects of Epiduo and Epiduo Forte can include:
- skin sensitivity to the sun*
- swelling in treated areas
- allergic reaction†
- burning skin†
- peeling skin†
- erythema (red, darker brown, purple, or gray patches of skin) †
* For more information about this side effect, see the “Common questions about Epiduo and Epiduo Forte” section below. † These serious side effects are discussed in more detail below in “Side effect details.”
Side effects in children
Both Epiduo and Epiduo Forte are approved to treat acne. Epiduo can be used in children ages 9 years and older, while Epiduo Forte can be used in children ages 12 years and older.
The side effects of Epiduo and Epiduo Forte seen in children are similar to those seen in adults. For more information, see the lists above in “Mild side effects” and “Serious side effects.”
Side effect details
You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. Here’s some detail on certain side effects this drug may or may not cause.
Purging
With skin purging, your skin quickly gets rid of dead skin cells, oil, and other substances that cause acne. This process may cause acne breakouts in some people.
Skin purging wasn’t reported as a side effect in clinical studies of Epiduo and Epiduo Forte. However, it has been seen with other medications that contain the same active drug as these medications contain.
For more information about skin purging, see the “Do Epiduo and Epiduo Forte cause skin purging?” section above.
Burning
Epiduo and Epiduo Forte can each make your skin sting or burn. Sometimes, this type of reaction can be similar to a chemical burn. Typically, symptoms caused by Epiduo or Epiduo Forte include painful, reddened skin.
Burning is typically worse during the first 4 weeks of treatment with either Epiduo or Epiduo Forte. But this side effect should become less bothersome as you continue using either drug.
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If you have skin burning that doesn’t go away after a few weeks of treatment with these medications, talk with your doctor. They can recommend ways to help reduce your discomfort.
How common is skin burning with Epiduo and Epiduo Forte?
Epiduo and Epiduo Forte have each been studied in adults and children ages 12 years and older. In these studies, 1% to 2% of people had skin burning after their acne was treated with either of these drugs. (This percentage range varied depending on which drug was being used.) Studies of Epiduo in children ages 9 to 11 years showed similar results.
In comparison, less than 1% of people had skin burning when their acne was treated with a placebo gel. (A placebo gel contains no active drug.)
In these clinical studies, people’s skin burning was at its worst during the first week of treatment. When it was at its worst:
- 41% of people had mild skin burning
- 15% to 19% of people had moderate skin burning
- 3% to 6% of people had severe skin burning
People’s skin burning lessened over time during the 12 weeks of treatment. At the end of treatment with Epiduo or Epiduo Forte:
- 7% of people had mild skin burning
- 1% to 2% of people had moderate skin burning
- 1% of people had severe skin burning
In comparison, of people who used the placebo gel:
- 3% had moderate skin burning when this side effect was at its worst
- 1% had severe skin burning when this side effect was at its worst
- 0% had moderate or severe skin burning at the end of the 12 weeks of treatment
Peeling skin
It’s possible to have peeling skin (scaling skin) while you’re using Epiduo or Epiduo Forte.
Applying these drugs to the skin around your eyes may cause flaky skin or dry skin in the area. But you should avoid applying Epiduo or Epiduo Forte to the skin around your eyes. If these drugs do come in contact with the skin around your eyes, rinse the area with water. This may help lessen your chances of having dryness or flaking.
If you have bothersome skin peeling with these drugs, talk with your doctor. They may suggest ways to help lessen this side effect. For example, using an oil-free or noncomedogenic moisturizer may help with skin peeling. (Noncomedogenic moisturizers are less likely to clog your pores and cause breakouts.)
How common is peeling skin with Epiduo and Epiduo Forte?
It’s not known how many adults and children ages 12 years and older had peeling skin in clinical studies of Epiduo and Epiduo Forte.
But of people who did have peeling skin while using Epiduo or Epiduo Forte, this side effect was at its worst during the first week of use. When peeling skin was at its worst:
- 35% of people had only mild peeling
- 11% to 17%* of people had moderate peeling
- 1% of people had severe peeling
* This percentage range varied depending on the drug being studied.
Peeling skin lessened over time during the 12 weeks of treatment. At the end of 12 weeks of treatment with Epiduo or Epiduo Forte:
- 9% of people had mild peeling
- 1% of people had moderate peeling
- less than 1% of people had severe peeling
In these studies, of people who used a placebo gel (gel with no active drug):
- 6% had moderate peeling when this side effect was at its worst
- 1% had moderate peeling at the end of 12 weeks of treatment
- no one had severe peeling when this side effect was at its worst or at the end of 12 weeks of treatment
Allergic reaction
As with most drugs, some people can have an allergic reaction after using Epiduo or Epiduo Forte. But it’s not known for sure how many people have had an allergic reaction to these drugs.
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Symptoms of a mild allergic reaction can include:
- skin rash
- itchiness
- flushing
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:
- swelling under your skin, typically in your eyelids, lips, hands, or feet
- swelling of your tongue, mouth, or throat
- trouble breathing
Call your doctor right away if you have a severe allergic reaction to Epiduo or Epiduo Forte. But call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
Redness
Erythema (skin redness) is a common side effect of Epiduo and Epiduo Forte. It typically occurs over the first several weeks after you start treatment with either medication. But this side effect should lessen as you continue using either drug.
If you have skin redness that doesn’t go away after a few weeks of treatment with Epiduo or Epiduo Forte, talk with your doctor. They can recommend ways to help reduce this side effect.
How common is skin redness with Epiduo and Epiduo Forte?
It’s not known how many adults and children ages 12 years and older had skin redness in clinical studies of Epiduo and Epiduo Forte.
Of those who had skin redness while using Epiduo or Epiduo Forte, this side effect was at its worst during the first week of treatment. When skin redness was at its worst:
- 27% of people had only mild redness
- 13% to 20%* of people had moderate redness
- 1% of people had severe redness
* This percentage range varied depending on the drug being studied.
People’s skin redness lessened over time during the 12 weeks of treatment. At the end of 12 weeks of treatment with Epiduo or Epiduo Forte:
- 8% of people had only mild redness
- 2% to 4%* of people had moderate redness
- 1% of people had severe redness
* This percentage range varied depending on the drug being studied.
In these studies, of people who used a placebo gel (gel with no active drug):
- 6% had moderate redness when this side effect was at its worst
- 1% had moderate redness at the end of 12 weeks of treatment
- 1% had severe redness when this side effect was at its worst
- no one had severe redness at the end of 12 weeks of treatment
Rash
Some people using Epiduo or Epiduo Forte may develop a skin rash. But it’s not known how often people had a rash in clinical studies of Epiduo and Epiduo Forte.
If you have a skin rash while you’re using Epiduo or Epiduo Forte, talk with your doctor right away. They may want to make sure your rash isn’t related to an allergic reaction. In addition, your doctor may be able to suggest ways to help clear up the rash.
Eczema
It’s possible that Epiduo and Epiduo Forte may cause eczema. With eczema, you have areas of the skin that are cracked, itchy, and red, darker brown, purple, or gray.
In clinical studies of Epiduo Forte, 1% of people developed eczema while using the drug. In comparison, no one using a placebo gel (gel with no active drug) developed eczema. It’s not known how often people had eczema in clinical studies of Epiduo.
If you have eczema while you’re using Epiduo or Epiduo Forte, talk with your doctor. They may recommend ways to treat or reduce your eczema. For example, using an oil-free and noncomedogenic moisturizer may help to reduce symptoms of eczema. (Noncomedogenic moisturizers are less likely to clog your pores and cause breakouts.)
In addition, it may be helpful to use gentle skin care products that don’t irritate your skin with Epiduo or Epiduo Forte.
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