Check out this answer from Consensus:
Current research supports the efficacy and safety of Benzoyl Peroxide in treating acne across different age groups and genders. Long-term studies indicate that BPO is well-tolerated and effective in reducing acne lesions and preventing atrophic scars. While there is limited direct evidence on the impact of BPO on skin aging, the available data do not suggest a significant risk of accelerated aging. Further research specifically focusing on the long-term effects of BPO on skin aging would be beneficial to provide more conclusive evidence.
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Benzoyl Peroxide (BPO) is a widely used topical treatment for acne vulgaris. It is known for its antibacterial properties, particularly against Cutibacterium acnes, and its ability to reduce inflammation and comedones. However, concerns have been raised about whether long-term use of BPO could potentially accelerate skin aging. This article explores the current research on the efficacy and safety of BPO, particularly focusing on its impact on skin aging.
Efficacy of Benzoyl Peroxide in Acne Treatment
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BPO has been demonstrated to be effective in treating acne across various age groups and genders. A study involving a fixed-combination of adapalene and BPO (A/BPO) showed significant improvements in acne severity and lesion counts in both younger and older subjects, as well as in males and females1. Another study confirmed the efficacy and safety of adapalene 0.1% and BPO 2.5% gel in adult females, showing a rapid onset of action and a tolerability profile consistent with that seen in teen-aged females2.
Long-Term Safety and Tolerability
The long-term safety of BPO has been evaluated in several studies. One study assessed the effects of up to 48 weeks of treatment with adapalene 0.3% and BPO 2.5% gel, finding it to be safe and well-tolerated, with significant reductions in acne lesions and atrophic scars3. Another study with a similar design also reported that BPO was effective in preventing and reducing atrophic acne scars over a 24-week period, with a tolerability profile that included some instances of skin irritation but no severe adverse events4.
Impact on Skin Aging
While the primary focus of the studies has been on the efficacy and safety of BPO in treating acne, there is limited direct evidence on whether BPO accelerates skin aging. The studies reviewed did not specifically address long-term skin aging effects. However, the consistent findings of good tolerability and the absence of severe adverse events in long-term use suggest that BPO does not significantly contribute to accelerated skin aging1 2 3 4.
Does using Benzoyl Peroxide for Acne age skin faster?
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Hywel C Williams has answered Extremely Unlikely
An expert from Centre of Evidence-Based Dermatology in Dermatology
It is true that benzoyl peroxide has a drying effect on the skin which is desirable when treating the excessive sebum and blocked pores characteristic of acne. But I am not aware of any evidence that its use is linked to skin wrinkling long-term, and Internet discussions about free radical generation do not make any sense. Most wrinkling is due to photodamage (excessive UV damage) which is due to collagen and elastic fibre damage in the dermis – not on the surface of the skin where BP works. Untreated acne causes scarring which will make some facial lines more prominent or cause them to distort when you get older and chronological ageing sets in, so please keep on treating your acne. BP has stood the test of time and has no associated bacterial resistance problems if you can tolerate it (remember to build up slowly)
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